Published research
Intrinsic Capacity, Polygenic Risk Score, APOE Genotype, and Risk of Dementia
A prospective study testing whether intrinsic capacity identifies dementia risk across different levels of genetic susceptibility.
Research question
Is lower intrinsic capacity associated with incident dementia, and does it compound genetic susceptibility measured using polygenic risk and APOE genotype?
Study
This prospective UK Biobank study included 366,406 participants. Seven functional factors across four intrinsic-capacity domains were combined into a deficit score and analysed in relation to all-cause dementia, Alzheimer disease, and vascular dementia.
Key finding
Greater intrinsic-capacity deficits were associated with higher dementia risk. Participants with both high genetic risk and substantial intrinsic-capacity deficits had the highest observed risk, suggesting that functional capacity provides information beyond inherited susceptibility.
Authorship
Co-first author.
Publication
Neurology · 2024
Publication record