Published research
Plasma Multiomics Links Early-Life Adversity to Disease and Cardiometabolic Health
A population-based multiomics study of how childhood adversity becomes biologically embedded and contributes to later cardiometabolic disease.
Research question
Which plasma metabolomic and proteomic patterns are associated with childhood adversity, and how much do these molecular signatures help explain later disease risk?
Study
This prospective cohort study included 153,225 participants. Childhood adversity was linked to incident disease and mortality, while integrated metabolomic and proteomic analyses identified molecular signatures and quantified their potential mediating roles.
Key finding
Childhood adversity was associated with a broad range of incident diseases and mortality, with especially strong links to cardiometabolic health. Adversity-related metabolic and proteomic signatures were independently associated with diabetes and hypertension and partially mediated these relationships.
Authorship
Co-first author.
Publication
Journal of the American Heart Association · 2026
Publication record