Published research
Cardiovascular-kidney-metabolic syndrome, dementia risk, cognition, and neuroimaging outcomes
A UK Biobank analysis connecting cardiovascular-kidney-metabolic syndrome stages with dementia, cognitive decline, and structural brain changes.
Research question
How does the severity of cardiovascular-kidney-metabolic (CKM) syndrome relate to dementia risk, cognitive performance, and brain structure?
Study
The study analysed 387,340 UK Biobank participants across five CKM stages. Cox and linear regression models examined incident dementia, cognitive decline, and neuroimaging outcomes, followed by mediation analysis of structural brain measures.
Key finding
More advanced CKM stages were associated with higher dementia risk, cognitive decline, lower total brain, gray-matter, and hippocampal volumes, and greater white-matter hyperintensity volume. Structural brain changes partially mediated the CKM-dementia association.
Authorship
Co-first author.
Publication
Journal of Affective Disorders · 2026
Publication record